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. 2002 Jan;46(1):245-7.
doi: 10.1128/AAC.46.1.245-247.2002.

In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp

Sevtap Arikan  1 , Mario Lozano-Chiu, Victor Paetznick, John H Rex
Affiliations

In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp

Sevtap Arikan et al. Antimicrob Agents Chemother. 2002 Jan.

Abstract

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and FUSARIUM: Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.

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