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. 2002 Jan;46(1):255-8.
doi: 10.1128/AAC.46.1.255-258.2002.

Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)

Alan Patrick Gibb  1 , Chanwit Tribuddharat, Richard A Moore, Thomas J Louie, Wally Krulicki, David M Livermore, Marie-France I Palepou, Neil Woodford
Affiliations

Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7)

Alan Patrick Gibb et al. Antimicrob Agents Chemother. 2002 Jan.

Abstract

Pseudomonas aeruginosa isolates from an outbreak in Canada were highly resistant to carbapenems and ceftazidime but not piperacillin. They produced a novel integron-associated metallo-beta-lactamase, designated IMP-7, with 91% identity to IMP-1. bla(IMP-7) was not detected with standard bla(IMP)-specific primers, owing to mismatches in the forward primer.

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Figures

FIG. 1.
FIG. 1.
Orientation of class I integron cassettes in clone pARL98.3. 5′CS and 3′CS, conserved sequences of a class I integron; ORF1, unknown open reading frame; aacC4, aminoglycoside resistance gene; blaIMP-7, class B β-lactamase gene; aacC1, aminoglycoside resistance gene.
FIG. 2.
FIG. 2.
Sequence of IMP-7 β-lactamase in comparison to those of other published IMP variants.
See this image and copyright information in PMC

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