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. 1975 Oct;36(4):1315-20.
doi: 10.1002/1097-0142(197510)36:4<1315::aid-cncr2820360419>3.0.co;2-t.

HL-A in cancer family "N"

H T Lynch, R J Thomas, P I Terasaki, A Ting, H A Guirgis, A R Kaplan, H Magee, J Lynch, C Kraft, E Chaperon

HL-A in cancer family "N"

H T Lynch et al. Cancer. 1975 Oct.

Abstract

Actual HL-A typing has been performed on 115 members of cancer family N, a large kindred (over 1000 members ascertained) showing the findings consistent with the cancer family syndrome. In the cancer-prone line (branches C and D) of the family, 20 of 21 members with cancer had one HL-A haplotype, HL-A2-HL-A12 (relative odds = 6.30), including some decreased family members who had haplotypes assigned. Eleven of 12 family members with cancer in branches C and D, actually typed, had HL-A2-HL-A12 (relative odds = 6.06). The single exception showing cancer and another haplotype in branch D is a child of a family member with haplotype HL-A2-HL-A12.

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