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Comment

. 2001 Dec 18;98(26):14748-50.

doi: 10.1073/pnas.261606598.

Can engineered bacteria help control cancer?

R K Jain¹, N S Forbes

Affiliations

Affiliation

¹ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. jain@steele.mgh.harvard.edu

PMID: 11752416
PMCID: PMC64926
DOI: 10.1073/pnas.261606598

Comment

Can engineered bacteria help control cancer?

R K Jain et al. Proc Natl Acad Sci U S A. 2001.

. 2001 Dec 18;98(26):14748-50.

doi: 10.1073/pnas.261606598.

Authors

R K Jain¹, N S Forbes

Affiliation

¹ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. jain@steele.mgh.harvard.edu

PMID: 11752416
PMCID: PMC64926
DOI: 10.1073/pnas.261606598

No abstract available

PubMed Disclaimer

Figures

Figure 1
Schematic of three microenvironmental regions in a centrally necrotic tumor. A spontaneous tumor may consist of many such necrotic foci. Decreasing magnitude of various physiological parameters is indicated as +++, ++, +, +/−, and −.

See this image and copyright information in PMC

Comment on

Combination bacteriolytic therapy for the treatment of experimental tumors.
Dang LH, Bettegowda C, Huso DL, Kinzler KW, Vogelstein B. Dang LH, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15155-60. doi: 10.1073/pnas.251543698. Epub 2001 Nov 27. Proc Natl Acad Sci U S A. 2001. PMID: 11724950 Free PMC article.

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References

1. Helmlinger G, Yuan F, Dellian M, Jain R K. Nat Med. 1997;3:177–182. - PubMed
1. Brown J M, Giaccia A J. Cancer Res. 1998;58:1408–1416. - PubMed
1. Parker R C, Plummer H C, Siebenmann C O, Chapman M G. Proc Soc Exp Biol Med. 1947;66:461–467. - PubMed
1. Malmgren R A, Flanigan C C. Cancer Res. 1955;15:473–478. - PubMed
1. Möse J R, Möse G. Cancer Res. 1964;24:212–216. - PubMed

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