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Comment
. 2001 Dec 18;98(26):14766-8.
doi: 10.1073/pnas.011602498.

How many ways to craft a cofactor?

J P Klinman  1
Affiliations
Comment

How many ways to craft a cofactor?

J P Klinman. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Quino-cofactors derived from protein-bound tyrosine (TPQ, LTQ) and tryptophan (TTQ, CTQ).
Figure 2
Figure 2
Mechanism for reductive half-reaction of TPQ enzymes.
Figure 3
Figure 3
An ortho-quinone (2) proposed as the common intermediate in TPQ and LTQ production.
See this image and copyright information in PMC

Comment on

References

    1. Ehrenberg A, Reichard P. J Biol Chem. 1972;247:3485–3488. - PubMed
    1. Wagner A F V, Frey M, Neugebauer F A, Schäfer W, Knappe J. Proc Natl Acad Sci USA. 1992;89:996–1000. - PMC - PubMed
    1. Janes S M, Mu D, Wemmer D, Smith A J, Kaur S, Maltby D, Burlingame A L, Klinman J P. Science. 1990;248:981–987. - PubMed
    1. Datta S, Mori Y, Takagi K, Kawaguchi K, Chen Z-W, Okajima T, Kuroda S, Ikeda T, Kano K, Tanizawa K, Mathews F S. Proc Natl Acad Sci USA. 2001;98:14268–14273. . (First Published November 20, 2001; 10.1073/pnas.241429098) - PMC - PubMed
    1. McIntire S, Wemmer D E, Christoserdov A Y, Lidstrom M E. Science. 1991;252:817–824. - PubMed

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