Review
doi: 10.1126/stke.2001.94.pe2.
Neuronal signaling through alternative splicing: some exons CaRRE
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- PMID: 11752670
- DOI: 10.1126/stke.2001.94.pe2
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Review
Neuronal signaling through alternative splicing: some exons CaRRE
Sci STKE.
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Abstract
Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.
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