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Case Reports
. 1975 Sep 1;63(2):227-9.
doi: 10.1016/0009-8981(75)90167-9.

An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease

R J Walton, C J Preston, R G Russell, J A Kanis
Case Reports

An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease

R J Walton et al. Clin Chim Acta. .

Abstract

A through-knee amputation for suspected osteogenic sarcoma was performed on a patient with Paget's disease of the tibia. Plasma alkaline phosphatase (AP) activity fell to normal values, apparently as a single exponential function of time, with a half-life of 1.7 days. The daily turnover of bone-derived plasma AP was estimated to be approximately 200 I.U. from the Pagetic tibia and 20 I.U. from the rest of the skeleton.

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