Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2001 Dec;15(6):871-82.
doi: 10.1016/s1074-7613(01)00246-1.

Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells

Y M Mueller  1 , S C De Rosa, J A Hutton, J Witek, M Roederer, J D Altman, P D Katsikis
Affiliations
Free article
Comparative Study

Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells

Y M Mueller et al. Immunity. 2001 Dec.
Free article

Abstract

Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) T cells express the CD45RA(-)CD62L(-) but lack the CD45RA(+)CD62L(-) T cell effector memory (T(EM)) phenotype. This skewing is not found in CMV- and EBV-specific CD8(+) T cells in HIV-infected individuals. CD95/Fas-induced apoptosis is much higher in the CD45RA(-)CD62L(-) T(EM) cells. However, cytotoxicity and IFNgamma production by HIV-specific CD8(+) T cells is not impaired. Our data suggest that the survival and differentiation of HIV-specific CD8(+) T cells may be compromised by CD95/Fas apoptosis induced by FasL-expressing HIV-infected cells.

PubMed Disclaimer

Comment in

Publication types

MeSH terms

LinkOut - more resources