Proton release as a modulator of presynaptic function
- PMID: 11754826
- DOI: 10.1016/s0896-6273(01)00549-9
Proton release as a modulator of presynaptic function
Abstract
In this issue of Neuron, DeVries (2001) describes experiments suggesting that acidification of the synaptic cleft can reduce Ca2+ channel activity and thereby act as a brake on tonic synaptic release of glutamate from cone cells. This work hints at a potentially important new facet to the regulation of synaptic transmission.
Comment on
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Exocytosed protons feedback to suppress the Ca2+ current in mammalian cone photoreceptors.Neuron. 2001 Dec 20;32(6):1107-17. doi: 10.1016/s0896-6273(01)00535-9. Neuron. 2001. PMID: 11754841
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