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Review
. 2001 Dec 20;32(6):960-2.
doi: 10.1016/s0896-6273(01)00549-9.

Proton release as a modulator of presynaptic function

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Free article
Review

Proton release as a modulator of presynaptic function

S F Traynelis et al. Neuron. .
Free article

Abstract

In this issue of Neuron, DeVries (2001) describes experiments suggesting that acidification of the synaptic cleft can reduce Ca2+ channel activity and thereby act as a brake on tonic synaptic release of glutamate from cone cells. This work hints at a potentially important new facet to the regulation of synaptic transmission.

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