Review
doi: 10.1016/s0196-9781(01)00486-7.
The regulation of human corticotrophin-releasing hormone gene expression in the placenta
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- PMID: 11754985
- DOI: 10.1016/s0196-9781(01)00486-7
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Review
The regulation of human corticotrophin-releasing hormone gene expression in the placenta
Peptides.
2001 Nov.
Abstract
Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.
Corrected and republished from
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The regulation of human corticotrophin-releasing hormone gene expression in the placenta.Peptides. 2001 May;22(5):795-801. doi: 10.1016/s0196-9781(01)00393-x. Peptides. 2001. Corrected and republished in: Peptides. 2001 Nov;22(11):1941-7. doi: 10.1016/s0196-9781(01)00486-7. PMID: 11337093 Corrected and republished. Review.
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