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. 2002 Jan 21;12(2):147-50.
doi: 10.1016/s0960-894x(01)00690-4.

Mixed lineage kinase activity of indolocarbazole analogues

Chikara Murakata  1 , Masami Kaneko, George Gessner, Thelma S Angeles, Mark A Ator, Teresa M O'Kane, Beth Ann W McKenna, Beth Ann Thomas, Joanne R Mathiasen, Michael S Saporito, Donna Bozyczko-Coyne, Robert L Hudkins
Affiliations

Mixed lineage kinase activity of indolocarbazole analogues

Chikara Murakata et al. Bioorg Med Chem Lett. .

Abstract

The MLK1-3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (16, CEP-11004/KT-8138) is reported.

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