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Review
. 2001 Nov-Dec;3(14-15):1191-200.
doi: 10.1016/s1286-4579(01)01479-4.

Cytokines in host defense against Salmonella

L Eckmann  1 , M F Kagnoff
Affiliations
Free article
Review

Cytokines in host defense against Salmonella

L Eckmann et al. Microbes Infect. 2001 Nov-Dec.
Free article

Abstract

Cytokines are key communication molecules between host cells in the defense against the enteric pathogen, Salmonella. Infection with Salmonella induces expression of multiple chemokines and proinflammatory cytokines in cultured intestinal epithelial cells and macrophages. In animal models, protective roles have been shown for IL-1alpha, TNFalpha, IFN-gamma, IL-12, IL-18 and IL-15, whereas IL-4 and IL-10 inhibit host defenses against Salmonella.

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