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Review
. 2001 Dec;17(12):582-8.
doi: 10.1016/s1471-4922(01)02085-2.

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

C H Sibley  1 , J E Hyde, P F Sims, C V Plowe, J G Kublin, E K Mberu, A F Cowman, P A Winstanley, W M Watkins, A M Nzila
Affiliations
Review

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

C H Sibley et al. Trends Parasitol. 2001 Dec.

Abstract

Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and morbidity occurs. Resistance is rapidly eroding the efficacy of chloroquine, and the combination pyrimethamine-sulfadoxine is the most commonly chosen alternative. Resistant populations of Plasmodium falciparum were selected extremely rapidly in Southeast Asia and South America. If this happens in sub-Saharan Africa, it will be a public health disaster because no inexpensive alternative is currently available. This article reviews the molecular mechanisms of this resistance and discusses how to extend the therapeutic life of antifolate drugs.

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