[Dose distribution of bone-seeking radiopharmaceuticals in the rat (author's transl)]
[Article in
German]
- PMID: 117574
Item in Clipboard
[Dose distribution of bone-seeking radiopharmaceuticals in the rat (author's transl)]
[Article in
German]
Strahlentherapie.
1979 Nov.
Abstract
The biokinetics of 32P-P, 32P-PPi, 85Sr, 99mTc- and 113Sn-EHDP were evaluated in the young rat. The dose distribution of the beta-emitters 32P, 89Sr, 121Sn and 188Re was calculated from the measured biological half-lifes. The highest dose to soft tissues and therefore also to bone-marrow in relation to the bone dosis was found for 32P-P. The lowest dose was found for 89Sr. Favourable results were obtained in the diphosphonate compounds. The use of 32P-PPi instead of 32P-P appears to be advantageous, too. The dose relation between normal bone and the growth plate of the femur was significantly lower for 89Sr than for the other radiopharmaceuticals.
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