Review
doi: 10.1007/pl00022800.
Modelling of chemotherapy: the effective dose approach
Affiliations
- PMID: 11757718
- DOI: 10.1007/pl00022800
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Review
Modelling of chemotherapy: the effective dose approach
Ann Hematol.
2001.
Abstract
We sketch the development of the effective dose approach which provides a theoretical framework to interpret chemotherapy outcome data. Building on the generalised Skipper model of chemotherapy, a meta-regression method is derived to jointly analyse all chemotherapy comparing randomised clinical trials in a given malignancy in order to explore the slope of the effective dose/outcome relationship and the relative potency of cytostatic drugs. The model is applied to explain why treatment differences in aggressive NHL appear to differ by risk groups in aggressive NHL. A respective meta-subgroup analysis to confirm this interaction hypothesis is proposed.
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