An intestinal disease produced experimentally by a prostaglandin deficiency

Abstract

Several prostaglandins were found to prevent development of multiple ulcertions of the small intestine, produced in rats by nonsteroidal antiinflammatory compounds such as indomethacin. The syndrome appears to be due to a prostaglandin deficiency produced by indomethacin; treatment with a prostaglandin prevents such deficiency and thus protects the animals.