Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Oct;67(1):237-43.
doi: 10.1083/jcb.67.1.237.

Inhibition by colchicine of fibrinogen translocation in hepatocytes

G Feldmann, M Maurice, C Sapin, J P Benhamou

Inhibition by colchicine of fibrinogen translocation in hepatocytes

G Feldmann et al. J Cell Biol. 1975 Oct.

Abstract

In the rat, 8 h after intraperitoneal administration of colchicine, fibrinogen (detected by antirat fibrinogen antibodies labeled with peroxidase) accumulated in the lumina of the rough endoplasmic reticulum of the hepatocytes; 16 and 24 h after colchicine administration, fibrinogen was detected, respectively, in the lumina of the smooth endoplasmic reticulum and in the Golgi apparatus. The effect of colchicine on the cytoplasmic translocation of fibrinogen could be due to a direct action of the drug on the membranes of the endoplasmic reticulum or could be the indirect result of the disruptive action of the drug on the microtubules.

PubMed Disclaimer

References

    1. Biochem J. 1959 Sep;73:119-26 - PubMed
    1. J Cell Biol. 1964 Feb;20:271-9 - PubMed
    1. Biochim Biophys Acta. 1964 Mar 16;82:463-75 - PubMed
    1. Vox Sang. 1963 Jul-Aug;8:461-73 - PubMed
    1. Gastroenterology. 1972 Dec;63(6):1036-48 - PubMed