The humoral response of mouse spleen cells to two types of sheep erythrocytes. III. A new VH region marker

Abstract

It was previously shown that there is multigene control of the response of mouse spleen cells to two types of sheep erythrocytes (H and L). Discriminator strains of mice make a much higher response to extra antigens found only on H SRBC than to the shared antigens found on both types of erythrocyte. Non-discriminator strains respond only to the shared antigens, making a response as great as the discriminator response to the extra antigens. In this study we have shown that the response to the extra antigen(s) on H SRBC is under the genetic control of a gene(s) located in the VH region near or to the left of the A5a, alpha 1, 3-dextran and NP makers.