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Review
. 2000 Jun;32(3):227-36.
doi: 10.1023/a:1005580828141.

Quaternary structure of nucleoside diphosphate kinases

L Lascu  1 , A Giartosio, S Ransac, M Erent
Affiliations
Review

Quaternary structure of nucleoside diphosphate kinases

L Lascu et al. J Bioenerg Biomembr. 2000 Jun.

Abstract

Nucleoside (NDP) diphosphate kinases are oligomeric enzymes. Most are hexameric, but some bacterial enzymes are tetrameric. Hexamers and tetramers are constructed by assembling identical dimers. The hexameric structure is important for protein stability, as demonstrated by studies with natural mutants (the Killer-of-prune mutant of Drosophila NDP kinase and the S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtained by site-directed mutagenesis. It is also essential for enzymic activity. The function of the tetrameric structure is unclear.

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