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Review
. 2000 Jun;32(3):237-46.
doi: 10.1023/a:1005532912212.

The catalytic mechanism of nucleoside diphosphate kinases

I Lascu  1 , P Gonin
Affiliations
Review

The catalytic mechanism of nucleoside diphosphate kinases

I Lascu et al. J Bioenerg Biomembr. 2000 Jun.

Abstract

Nucleoside diphosphate kinases catalyze the reversible transfer of the gamma phosphate of nucleoside triphosphates to nucleoside diphosphates. This minireview presents recent advances in understanding the reaction mechanism using steady-state and fast kinetic studies, X-ray crystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance of in vitro studies.

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