Time, place and positional value in the chick limb-bud
- PMID: 1176863
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Time, place and positional value in the chick limb-bud
J Embryol Exp Morphol.
1975 Jun.
Abstract
Quantitative experimental evidence is presented for the progress zone theory of limb development. The theory, here formulated mathematically, states that the parts of the limb are specified in proximo-distal succession by an autonomous timing mechanism operating in a 'progress zone' of undifferentiated growing mesenchyme under the influence of the apical ectodermal ridge. By the exchange of distal tips between young and old wing-buds, it is shown that there are no long-range morphogenetic signals from proximal to distal tissue. The width of the progress zone is calculated, and it is found autoradiographically that practically all its cells are dividing.
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