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. 2002 Jan 10;4(1):71-3.
doi: 10.1021/ol0102388.

Three-component coupling via the squarate ester cascade as a concise route to the bioactive triquinane sesquiterpene hypnophilin

Feng Geng  1 , Jian Liu, Leo A Paquette
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Three-component coupling via the squarate ester cascade as a concise route to the bioactive triquinane sesquiterpene hypnophilin

Feng Geng et al. Org Lett. .

Abstract

[reaction: see text] A squarate ester cascade is used to provide in one step, via the coupling of three reactants, a highly oxygenated linear triquinane product. The latter is transformed in nine steps into hypnophilin. The access route involves a combination of chlorination, reduction, dehydration, and oxidation maneuvers in the proper sequence.

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