doi: 10.1021/ol017013h.
Indium-mediated intermolecular alkyl radical addition to electron-deficient C [double bond] N bond and C [double bond] C bond in water
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- PMID: 11772108
- DOI: 10.1021/ol017013h
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Indium-mediated intermolecular alkyl radical addition to electron-deficient C [double bond] N bond and C [double bond] C bond in water
Org Lett.
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Abstract
[reaction: see text] The intermolecular alkyl radical addition to imine derivatives was studied in aqueous media by using indium as a single-electron-transfer radical initiator. The one-pot reaction based on radical addition to glyoxylic hydrazone provided a convenient method for preparing the alpha-amino acids. The indium-mediated radical addition to an electron-deficient C=C bond also proceeded effectively to provide the new carbon-carbon bond-forming method in aqueous media.
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