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. 1975 Nov;18(11):1130-4.
doi: 10.1021/jm00245a017.

Antiarrhythmics. N-(aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides

E H Banitt, W E Coyne, J R Schmid, A Mendel

Antiarrhythmics. N-(aminoalkylene)trifluoroethoxybenzamides and N-(aminoalkylene)trifluoroethoxynaphthamides

E H Banitt et al. J Med Chem. 1975 Nov.

Abstract

Benzamides and naphthamides characterized by one or more 2,2,2-trifluoroethoxy ring substituents have been prepared and evaluated as antiarrhythmic agents in mice. Structure-action studies reveal that antiarrhythmic activity is highly dependent upon the number and position of 2,2,2-trifluoroethoxy groups. The most potent compounds are derived from 2,5-bis(2,2,2-trifluoroethoxy)benzamide, and, within this group, wide variation of the amide side chain is possible without adversely affecting the antiarrhythmic activity.

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