[Evaluation of tumor necrosis factor-alpha and interleukin-6 levels in serum and peritoneal fluid of patients with endometriosis]
- PMID: 11775897
[Evaluation of tumor necrosis factor-alpha and interleukin-6 levels in serum and peritoneal fluid of patients with endometriosis]
Abstract
Objectives: To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) before and after conservative laparoscopic surgery in patients with endometriosis.
Methods: The TNF-alpha and IL-6 levels in serum and peritoneal fluid of 20 endometriotic patients and 10 control patients were determined by radioimmunoassay.
Results: Significant parallel relationship existed between the stage of endometriosis and the TNF-alpha and IL-6 levels in serum and peritoneal fluid in endometriosis patients (r values: serum: 0.80, 0.52; peritoneal fluid: 0.79, 0.49, P < 0.05). After clearance of endometriosis foci with laparoscopic conservative surgery, the TNF-alpha and IL-6 levels decreased significantly.
Conclusion: Measuring TNF-alpha and IL-6 level may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of surgery.
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