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. 2002 Jan;122(1-2):140-5.
doi: 10.1016/s0165-5728(01)00456-8.

HLA class II associated risk and protection against multiple sclerosis-a Finnish family study

Mikko Laaksonen  1 , Tomi Pastinen, Minna Sjöroos, Satu Kuokkanen, Juhani Ruutiainen, Marja Liisa Sumelahti, Helena Reijonen, Reijo Salonen, Juhani Wikström, Martin Panelius, Jukka Partanen, Pentti J Tienari, Jorma Ilonen
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HLA class II associated risk and protection against multiple sclerosis-a Finnish family study

Mikko Laaksonen et al. J Neuroimmunol. 2002 Jan.

Abstract

We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients. The most important predisposing haplotype was DRB1*15-DQB1*0602 (P<10(-6)) as expected and a weak predisposing effect of DRB1*04-DQB1*0302 was revealed after the elimination of DRB1*15-DQB1*0602. HLA-DRB1*01-DQB1*0501 and DRB1*13-DQB1*0603 were negatively associated with MS in transmission disequilibrium test, but only the DRB1*13-DQB1*0603 association remained significant (P=0.008) after the elimination of DRB1*15-DQB1*0602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS.

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