Review
doi: 10.1016/s0092-8674(01)00620-1.
Multisite phosphorylation and the countdown to S phase
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- PMID: 11779457
- DOI: 10.1016/s0092-8674(01)00620-1
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Review
Multisite phosphorylation and the countdown to S phase
Cell.
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Free article
Abstract
Remarkably, SCF(Cdc4) ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates. This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.
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