Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess

Abstract

Objective: To determine whether there is an ovarian thecal cell component to hyperandrogenism exhibited in adult female rhesus monkeys exposed to androgen excess during prenatal life.

Design: Prospective nonrandomized study.

Setting: An academic research environment.

Animal(s): Eleven adult female rhesus monkeys.

Intervention(s): Five female rhesus monkeys exposed prenatally to T propionate and six normal females underwent blood sampling immediately before and 24 h after a 200-IU IM injection of recombinant hCG.

Main outcome measure(s): Serum T, 17alpha-hydroxyprogesterone, DHEAS, and cortisol concentrations determined by RIA.

Result(s): Prenatally androgenized females exhibited increased T and 17alpha-hydroxyprogesterone response to recombinant hCG stimulation, compared to control females. Although serum adrenal DHEAS concentrations were elevated in comparison to control females, the increased levels of DHEAS were not dependent on recombinant hCG stimulation.

Conclusion(s): Prenatal androgen excess in female rhesus monkeys causes perturbations in ovarian and adrenal steroidogenesis during adulthood, which may both contribute to hyperandrogenism.