Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;288(4):427-33.
doi: 10.1007/BF00501287.

Influence of morphine and naloxone on the release of noradrenaline from rat cerebellar cortex slices

H Montel, K Starke, H D Taube

Influence of morphine and naloxone on the release of noradrenaline from rat cerebellar cortex slices

H Montel et al. Naunyn Schmiedebergs Arch Pharmacol. 1975.

Abstract

In slices of rat cerebellar cortex preincubated with (-)-3H-noradrenaline, the influence of morphine and naloxone on the efflux of tritium was investigated. The spontaneous outflow was not changed by 10(-5) M of either morphine or naloxone. On the other hand, morphine caused a concentration-dependent decrease of the overflow of tritium evoked by electrical field stimulation. Naloxone did not change the stimulation-induced overflow, but prevented its inhibition by morphine. It is concluded that morphine, through an action on opiate receptors located on cerebellar noradrenergic neurones, inhibits the secretion of the transmitter in response to nerve impulses.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Pharm Pharmacol. 1974 May;26(5):364-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Jul;70(7):1947-9 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1974;283(4):357-69 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1974;282(3):239-44 - PubMed
    1. Brain Res. 1974 Sep 6;77(2):269-79 - PubMed