This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2002 Jan;109(1):17-8.

doi: 10.1172/JCI14780.

The buzz about BAFF

Affiliations

PMID: 11781346
PMCID: PMC150827
DOI: 10.1172/JCI14780

Comment

The buzz about BAFF

David L Vaux. J Clin Invest. 2002 Jan.

. 2002 Jan;109(1):17-8.

doi: 10.1172/JCI14780.

Author

Affiliation

¹ The Walter and Eliza Hall Institute, Royal Parade Parkville, Victoria 3050, Australia. vaux@wehi.edu.au

PMID: 11781346
PMCID: PMC150827
DOI: 10.1172/JCI14780

No abstract available

PubMed Disclaimer

Figures

Figure 1
Two TNF-related ligands, BAFF and APRIL, can bind to three identified and one hypothetical TNF receptor-related receptors. BAFF-R can only be bound by BAFF, an interaction that promotes the survival of peripheral B cells.

See this image and copyright information in PMC

Comment on

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, Mauri D, Cavill D, Gordon TP, Mackay CR, Mackay F. Groom J, et al. J Clin Invest. 2002 Jan;109(1):59-68. doi: 10.1172/JCI14121. J Clin Invest. 2002. PMID: 11781351 Free PMC article.

Similar articles

Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis.
Zhang M, Ko KH, Lam QL, Lo CK, Srivastava G, Zheng B, Lau YL, Lu L. Zhang M, et al. Int Immunol. 2005 Aug;17(8):1081-92. doi: 10.1093/intimm/dxh287. Epub 2005 Jul 6. Int Immunol. 2005. PMID: 16000326
Development of nephritis but not sialadenitis in autoimmune-prone BAFF transgenic mice lacking marginal zone B cells.
Fletcher CA, Sutherland AP, Groom JR, Batten ML, Ng LG, Gommerman J, Mackay F. Fletcher CA, et al. Eur J Immunol. 2006 Sep;36(9):2504-14. doi: 10.1002/eji.200636270. Eur J Immunol. 2006. PMID: 16906535
The role of BAFF in immune function and implications for autoimmunity.
Kalled SL. Kalled SL. Immunol Rev. 2005 Apr;204:43-54. doi: 10.1111/j.0105-2896.2005.00219.x. Immunol Rev. 2005. PMID: 15790349 Review.
BAFF: a novel therapeutic target for autoimmunity.
Kalled SL. Kalled SL. Curr Opin Investig Drugs. 2002 Jul;3(7):1005-10. Curr Opin Investig Drugs. 2002. PMID: 12186259 Review.
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF.
Tardivel A, Tinel A, Lens S, Steiner QG, Sauberli E, Wilson A, Mackay F, Rolink AG, Beermann F, Tschopp J, Schneider P. Tardivel A, et al. Eur J Immunol. 2004 Feb;34(2):509-18. doi: 10.1002/eji.200324692. Eur J Immunol. 2004. PMID: 14768056

See all similar articles

Cited by

Furin at the cutting edge: from protein traffic to embryogenesis and disease.
Thomas G. Thomas G. Nat Rev Mol Cell Biol. 2002 Oct;3(10):753-66. doi: 10.1038/nrm934. Nat Rev Mol Cell Biol. 2002. PMID: 12360192 Free PMC article. Review.
B-cell survival factors in autoimmune rheumatic disorders.
Morais SA, Vilas-Boas A, Isenberg DA. Morais SA, et al. Ther Adv Musculoskelet Dis. 2015 Aug;7(4):122-51. doi: 10.1177/1759720X15586782. Ther Adv Musculoskelet Dis. 2015. PMID: 26288664 Free PMC article. Review.
Belimumab in systemic lupus erythematosus.
Vilas-Boas A, Morais SA, Isenberg DA. Vilas-Boas A, et al. RMD Open. 2015 Mar 3;1(1):e000011. doi: 10.1136/rmdopen-2014-000011. eCollection 2015. RMD Open. 2015. PMID: 26509047 Free PMC article. Review.
DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF.
Gavin AL, Aït-Azzouzene D, Ware CF, Nemazee D. Gavin AL, et al. J Biol Chem. 2003 Oct 3;278(40):38220-8. doi: 10.1074/jbc.M306852200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12867412 Free PMC article.
APRIL modulates B and T cell immunity.
Stein JV, López-Fraga M, Elustondo FA, Carvalho-Pinto CE, Rodríguez D, Gómez-Caro R, De Jong J, Martínez-A C, Medema JP, Hahne M. Stein JV, et al. J Clin Invest. 2002 Jun;109(12):1587-98. doi: 10.1172/JCI15034. J Clin Invest. 2002. PMID: 12070306 Free PMC article.

References

1. Moore PA, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science. 1999; 285:260–263. - PubMed
1. Schneider P, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999; 189:1747–1756. - PMC - PubMed
1. Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999; 65:680–683. - PubMed
1. Mukhopadhyay A, Ni J, Zhai YF, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates arpoptosis, nuclear factor-kappa B, and c-Jun NH2-terminal kinase. J Biol Chem. 1999; 274:15978–15981. - PubMed
1. Cheema GS, Roschke V, Hilbert DA, Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 2001; 44:1313–1319. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
Medical
- MedlinePlus Health Information