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Case Reports
. 2001 Dec;28(11):1087-9.
doi: 10.1038/sj.bmt.1703286.

Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL

M Schneider  1 , K Hettinger, S Matthes-Martin, M Konrad, C Peters, H Gadner, E R Panzer-Grümayer
Affiliations
Case Reports

Influence of transplantation regimen on prognostic significance of high-level minimal residual disease before allogeneic stem cell transplantation in children with ALL

M Schneider et al. Bone Marrow Transplant. 2001 Dec.

Abstract

High MRD levels before transplantation in children receiving T cell-depleted unrelated grafts for relapsed ALL were associated with a 100% relapse risk. We report on two children with relapsed ALL who underwent non T cell-depleted BMT from unrelated donors. Despite a high residual tumor load pre- transplant and the occurrence of only aGVHD grade I, they are still in second complete remission 2.7 and 5.2 years after transplantation, respectively. Thus, we propose that the transplant regimens influence the prognostic significance of high MRD levels pre-BMT.

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