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Review
. 2001 Oct:183:65-75.
doi: 10.1034/j.1600-065x.2001.1830105.x.

The evolution of the MHC-G gene does not support a functional role for the complete protein

A Arnaiz-Villena  1 , J Martinez-Laso, M J Castro, P Morales, J Moscoso, P Varela, E Gomez-Casado, L M Allende
Affiliations
Review

The evolution of the MHC-G gene does not support a functional role for the complete protein

A Arnaiz-Villena et al. Immunol Rev. 2001 Oct.

Abstract

The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.

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