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. 2000 Jan;20(1):37-9.

[Effect of gandou decoction on copper metabolism of skin fibroblast of hepatolenticular degeneration model]

[Article in Chinese]
Q Tang  1 , R Yang, Y Han
Affiliations
  • PMID: 11783335

[Effect of gandou decoction on copper metabolism of skin fibroblast of hepatolenticular degeneration model]

[Article in Chinese]
Q Tang et al. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Jan.

Abstract

Objective: To explore the cytological mechanism of Gandou Decoction (GDD) in treating hepatolenticular degeneration (HLD).

Methods: Twenty-three in vitro models of cultured skin fibroblast of HLD were established to observe the intracellular change of microelements (Cu2+, Zn2+, etc.) content before and after adding rabbit's serum containing GDD.

Results: After being treated with GDD contained serum for 24 hours, the intracellular content of Cu2+ decreased from (80.94 +/- 34.76) ng/mg to (46.90 +/- 22.14) ng/mg, P < 0.01, while that of Zn2+ increased from (140.43 +/- 33.81) ng/mg to (151.43 +/- 37.83) ng/mg, P < 0.01.

Conclusion: GDD is quite effective in removing the intracellular copper and increasing the intracellular zinc.

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