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. 2002 Jan 17;45(2):255-8.
doi: 10.1021/jm010400c.

Bacteriopurpurinimides: highly stable and potent photosensitizers for photodynamic therapy

Yihui Chen, Andrew Graham, William Potter, Janet Morgan, Lurine Vaughan, David A Bellnier, Barbara W Henderson, Allan Oseroff, Thomas J Dougherty, Ravindra K Pandey

Bacteriopurpurinimides: highly stable and potent photosensitizers for photodynamic therapy

Yihui Chen et al. J Med Chem. .

Abstract

The in situ conversion of the unstable bacteriochlorophyll a present in Rhodobacter sphaeroides produced highly stable bacteriopurpurin-18 which in a sequence of reactions was converted into a series of alkyl ether analogues of bacteriopurpurin-18-N-alkylimides with long wavelength absorption near 800 nm. The effective photosensitizers were found to localize in mitochondria but did not show any specific displacement of (3)H-PK11195, suggesting that the mitochondrial peripheral benzodiazepine receptor is not the cellular binding site for this class of compounds.

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