Microsatellite instability in colorectal cancer: prognostic, predictive or both?

Comment

Marius van Rijnsoever et al. Am J Pathol. 2002 Jan.

. 2002 Jan;160(1):384-5; author reply 385-6.

doi: 10.1016/s0002-9440(10)64383-0.

No abstract available

Comment on

Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis.
Guidoboni M, Gafà R, Viel A, Doglioni C, Russo A, Santini A, Del Tin L, Macrì E, Lanza G, Boiocchi M, Dolcetti R. Guidoboni M, et al. Am J Pathol. 2001 Jul;159(1):297-304. doi: 10.1016/S0002-9440(10)61695-1. Am J Pathol. 2001. PMID: 11438476 Free PMC article.

1. Feeley KM, Fullard JF, Heneghan MA, Smith T, Maher M, Murphy RP, O’Gorman TA: Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis. J Pathol 1999, 188:14-17 - PubMed
1. Salahshor S, Kressner U, Fischer H, Lindmark G, Climelius B, Pahlman L, Lindblom A: Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor. Br J Cancer 1999, 81:190-193 - PMC - PubMed
1. Wright CM, Dent OF, Barker M, Newland RC, Chapuis PH, Bokey EL, Young JP, Leggett BA, Jass JR, Macdonald GA: Prognostic significance of extensive microsatellite instability in sporadically clniicopathological stage C colorectal cancer. Br J Surg 2000, 87:1197-1202 - PubMed
1. Halling KC, French AJ, McDonnell SK, Burgart LJ, Schaid DJ, Peterson BJ, Moon-Tasson L, Mahoney MR, Sargent DJ, O’Connell MJ, Witzig TE, Farr Jr GH, Goldberg RM, Thibodeau SN: Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst 1999, 91:1295–1303 - PubMed
1. Gryfe R, Kim H, Hsieh ET, Aronson MD, Holowaty EJ, Bull SB, Redston M, Gallinger S: Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 2000, 342:69-77 - PubMed