Identification of foreign gene sequences by transcript filtering against the human genome
- PMID: 11788827
- DOI: 10.1038/ng818
Identification of foreign gene sequences by transcript filtering against the human genome
Abstract
We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.
Comment in
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The human body as microbial observatory.Nat Genet. 2002 Feb;30(2):131-3. doi: 10.1038/ng0202-131. Nat Genet. 2002. PMID: 11818955 No abstract available.
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