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. 2002 Feb;30(2):141-2.
doi: 10.1038/ng818. Epub 2002 Jan 14.

Identification of foreign gene sequences by transcript filtering against the human genome

Griffin Weber  1 , Jay Shendure, David M Tanenbaum, George M Church, Matthew Meyerson
Affiliations

Identification of foreign gene sequences by transcript filtering against the human genome

Griffin Weber et al. Nat Genet. 2002 Feb.

Abstract

We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.

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