[Clinical study on hemorrheologic changes for metastatic state of gastric cancer and its relationship with syndrome-type in traditional Chinese medicine]

Abstract

Objective: To explore the hemorrheologic changes of gastric cancer in various stages, and the relationship between different phases and Syndrome-types.

Methods: Sixty-three gastric cancer patients and 30 healthy controls matching in sex and age were studied. According to the phases of tumor and the differentiation standards of deficiency and excess syndrome in TCM, the patients were divided into 6 groups: Non-metastasis (NM), lymphnode metastasis (LM), distant metastasis (DM) groups, and Deficiency (D), Excess (E), mixed deficiency and excess (DE) groups. The hemorrheology criteria including whole blood viscosity (BV), plasma viscosity (PV), hematocrit (HCT), fibrinogen (Fib), platelet count (PC), platelet aggregation rate (PAR) were measured.

Results: The value of BV, PV, Fib, PC and PAR in gastric cancer groups were higher significantly (P < 0.05, P < 0.01) than those in the healthy control group, but BV, PV in the LM and DM groups were higher than those in the healthy control group significantly (P < 0.05), while difference between NM group and the healthy control group was insignificant (P > 0.05). Hypercoagulability state presented in all the three Syndrome Type groups of gastric cancer patients, but the difference in some criteria between D and E group were significant (P < 0.05, P < 0.01); and DE groups was greatly higher than D and E groups in high-shear BV, Fib and PC (P < 0.05, P < 0.01).

Conclusion: The value of BV, PV Fib, PC and PAR could be regarded as good referential parameters in reflecting the condition of evil excess.