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. 1975 Aug;11(4):663-6.

Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes

  • PMID: 1179036

Calcium-binding property of cocaine and some of its active metabolites-formation of molecular complexes

A L Misra et al. Res Commun Chem Pathol Pharmacol. 1975 Aug.

Abstract

Cocaine, benzoylecgonine, benzoylnorecgonine, norcocaine, ecgonine methyl ester but not ecgonine formed distinct molecular complexes with calcium chloride of the general formula [B. CaC12-2H20]. The particularly strong interaction observed with benzoylecgonine, benzoylnorecgonine and calcium may play a role in the potent stimulant activity of these 2 compounds observed in rats after intracisternal administration.

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