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Review
. 2002 Feb;14(1):96-102.
doi: 10.1016/s0952-7915(01)00303-x.

Defensins of vertebrate animals

Robert I Lehrer  1 , Tomas Ganz
Affiliations
Review

Defensins of vertebrate animals

Robert I Lehrer et al. Curr Opin Immunol. 2002 Feb.

Abstract

During the past year, novel beta-defensins of mice and men have been identified, together with a novel defensin subfamily (the circular or 'theta' minidefensins) in primates. Insight into the evolution of defensins has been obtained from structural studies, and several mechanisms related to microbial resistance to defensins have been delineated. There is now convincing evidence that defensins augment adaptive immune responses.

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