Review
doi: 10.1016/s1359-6446(01)02090-6.
Multi-component reactions and evolutionary chemistry
Affiliations
- PMID: 11790626
- DOI: 10.1016/s1359-6446(01)02090-6
Item in Clipboard
Review
Multi-component reactions and evolutionary chemistry
Drug Discov Today.
.
Abstract
Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.
Comment in
-
MCRs: changing the chemists' mindset.Drug Discov Today. 2002 Jun 15;7(12):649. doi: 10.1016/s1359-6446(02)02337-1. Drug Discov Today. 2002. PMID: 12110239 No abstract available.
Similar articles
-
Privileged structure-based combinatorial libraries targeting G protein-coupled receptors.Assay Drug Dev Technol. 2003 Aug;1(4):579-92. doi: 10.1089/154065803322302835. Assay Drug Dev Technol. 2003. PMID: 15090254
-
The application of multi-component reactions in drug discovery.Curr Med Chem. 2002 Dec;9(23):2085-93. doi: 10.2174/0929867023368719. Curr Med Chem. 2002. PMID: 12470248 Review.
-
Strategies for innovation in multicomponent reaction design.Acc Chem Res. 2009 Mar 17;42(3):463-72. doi: 10.1021/ar800214s. Acc Chem Res. 2009. PMID: 19175315 Free PMC article.
-
Current directions in the evolution of compound libraries.Curr Opin Drug Discov Devel. 2005 May;8(3):303-8. Curr Opin Drug Discov Devel. 2005. PMID: 15892244 Review.
-
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs.Int J Mol Sci. 2023 Apr 1;24(7):6581. doi: 10.3390/ijms24076581. Int J Mol Sci. 2023. PMID: 37047554 Free PMC article. Review.
Cited by
-
2-Amino-4-aryl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitriles with Microtubule-Disruptive, Centrosome-Declustering, and Antiangiogenic Effects in vitro and in vivo.ChemMedChem. 2022 May 18;17(10):e202200064. doi: 10.1002/cmdc.202200064. Epub 2022 Mar 16. ChemMedChem. 2022. PMID: 35226402 Free PMC article.
-
Macrocycles rapidly produced by multiple multicomponent reactions including bifunctional building blocks (MiBs).Mol Divers. 2005;9(1-3):159-69. doi: 10.1007/s11030-005-1313-y. Mol Divers. 2005. PMID: 15789563
-
Multicomponent reactions of dimethyl methoxymalonate and dialkyl acetylenedicarboxylate in the presence of N-nucleophiles: one-pot synthesis of 2H-pyridinyl-2-butenedioates in water.Mol Divers. 2010 Aug;14(3):605-9. doi: 10.1007/s11030-009-9192-2. Epub 2009 Sep 11. Mol Divers. 2010. PMID: 19763860
-
Synergy Effects in the Chemical Synthesis and Extensions of Multicomponent Reactions (MCRs)-The Low Energy Way to Ultra-Short Syntheses of Tailor-Made Molecules.Molecules. 2017 Feb 25;22(3):349. doi: 10.3390/molecules22030349. Molecules. 2017. PMID: 28245622 Free PMC article. Review.
-
Supported Cu(II)-Schiff base: novel heterogeneous catalyst with extremely high activity for eco-friendly, one-pot and multi-component C-S bond-forming reaction toward a wide range of thioethers as biologically active cores.Mol Divers. 2022 Apr;26(2):1249-1258. doi: 10.1007/s11030-021-10227-1. Epub 2021 May 12. Mol Divers. 2022. PMID: 33978897
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
