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Review
. 2002 Jan 15;7(2):143-7.
doi: 10.1016/s1359-6446(01)02090-6.

Multi-component reactions and evolutionary chemistry

Lutz Weber  1
Affiliations
Review

Multi-component reactions and evolutionary chemistry

Lutz Weber. Drug Discov Today. .

Abstract

Multi-component reactions (MCRs) provide a new approach towards the efficient synthesis of diverse compounds and compound libraries. MCRs are evolving from being purely a chemistry curiosity to being recognized as having increasing relevance for drug discovery in terms of lead discovery and optimization. The combination of MCR-type chemistry-planning with evolutionary in silico and in vitro prediction of drug potential or biological properties is a new and powerful tool in drug discovery.

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Comment in

  • MCRs: changing the chemists' mindset.
    Hird N. Hird N. Drug Discov Today. 2002 Jun 15;7(12):649. doi: 10.1016/s1359-6446(02)02337-1. Drug Discov Today. 2002. PMID: 12110239 No abstract available.

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