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. 2002 Mar;9(2):107-11.
doi: 10.1016/s1350-4177(01)00108-0.

Sonochemical bromination of acetophenones using p-toluenesulfonic acid-N-bromosuccinimide

M V Adhikari  1 , S D Samant
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Free article

Sonochemical bromination of acetophenones using p-toluenesulfonic acid-N-bromosuccinimide

M V Adhikari et al. Ultrason Sonochem. 2002 Mar.
Free article

Abstract

Substituted acetophenones react with N-bromosuccinimide (NBS) and p-toluenesulfonic acid (p-TsOH) in the presence of ultrasound in methanol at 35 +/- 2 degrees C to give alpha-bromoacetophenones in high yield. In the absence of ultrasound the reaction takes place at the boiling point of methanol (65 degrees C) and takes longer time. The reaction does not take place in the absence of p-TsOH thermally or sonically. However the reaction is possible under photochemical conditions in the absence of p-TsOH. The best solvent for the reaction was found to be methanol.

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