doi: 10.1021/ol017054d.
One-pot synthesis of glucosamine oligosaccharides
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- PMID: 11796070
- DOI: 10.1021/ol017054d
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One-pot synthesis of glucosamine oligosaccharides
Org Lett.
.
Abstract
[reaction: see text] Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner. One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50-81% yields.
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