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. 2002 Jan 24;4(2):281-3.
doi: 10.1021/ol017054d.

One-pot synthesis of glucosamine oligosaccharides

Micha Fridman  1 , Dmitry Solomon, Shay Yogev, Timor Baasov
Affiliations

One-pot synthesis of glucosamine oligosaccharides

Micha Fridman et al. Org Lett. .

Abstract

[reaction: see text] Tuning the reactivity of glycosyl donors derived from 2-amino-2-deoxy glucose by selective introduction of different N-protecting (NPhth and NHTroc) and anomeric leaving groups (ethylthio and phenylthio) enabled highly efficient oligosaccharide synthesis in a one-pot manner. One-pot sequential glycosylation of three and four units of 2-amino-2-deoxy glucose gave trisaccharides and tetrasaccharide in 50-81% yields.

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