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. 2002 Jan 24;4(2):305-7.
doi: 10.1021/ol0171665.

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine

Yongseok Choi  1 , Hyunah Choo, Youhoon Chong, Sookwang Lee, Sureyya Olgen, Raymond F Schinazi, Chung K Chu
Affiliations

Synthesis and potent anti-HIV activity of L-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thiocytidine

Yongseok Choi et al. Org Lett. .

Abstract

[reaction: see text] L-2'-Fluoro-4'-thio-2',3'-unsaturated cytidine 11 was synthesized from (R)-2-fluorobutenolide 2, which was prepared from 2,3-O-isopropylidene-L-glyceraldehyde 1. The synthesized compound 11 shows potent antiviral activity against HIV-1.

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