Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Feb;46(2):267-74.
doi: 10.1128/AAC.46.2.267-274.2002.

Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective

Stephen H Gillespie  1
Affiliations
Review

Evolution of drug resistance in Mycobacterium tuberculosis: clinical and molecular perspective

Stephen H Gillespie. Antimicrob Agents Chemother. 2002 Feb.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Diagrammatic representation of the link between mutation rate, population size, and clinical complication in the emergence of resistance in M. tuberculosis infection. This demonstrates that individuals with tuberculosis in which the bacterial population increases or drug penetration is compromised by empyema or poor adherence are more likely to produce resistant mutants.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Alland, D., G. E. Kalkut, A. R. Moss, R. A. McAdam, J. A. Hahn, W. Bosworth, E. Drucker, and B. R. Bloom. 1994. Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods. N. Engl. J. Med. 330:1710–1716. - PubMed
    1. Barnett, M., S. R. M. Bushby, and D. A. Mitchison. 1953. Tubercle bacilli resistant to isoniazid: virulence and response to treatment with isoniazid in guinea pigs and mice. Br. J. Exp. Pathol. 34:568–581. - PMC - PubMed
    1. Bjorkman, J., D. Hughes, and D. I. Andersson. 1998. Virulence of antibiotic-resistant Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 95:3949–3953. - PMC - PubMed
    1. Bjorkman, J., I. Nagaev, O. G. Berg, D. Hughes, and D. I. Andersson. 2000. Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science 287:1479–1482. - PubMed
    1. Bottger, E. C., B. Springer, M. Pletschette, and P. Sander. 1998. Fitness of antibiotic-resistant microorganisms and compensatory mutations. Nat. Med. 4:1343–1344. - PubMed

MeSH terms