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Review
. 2002 Feb;72(2):152-61.
doi: 10.1136/jnnp.72.2.152.

Protein aggregates and dementia: is there a common toxicity?

S Lovestone  1 , D M McLoughlin
Affiliations
Review

Protein aggregates and dementia: is there a common toxicity?

S Lovestone et al. J Neurol Neurosurg Psychiatry. 2002 Feb.

Abstract

This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)--beta-amyloid peptide and tau--but also considers other proteins in this disorder and in less common but equally devastating diseases.

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References

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