[Comparison of immunology effects between live attenuated hepatitis A vaccine and inactivated hepatitis A vaccine]

Abstract

Objective: To study the immunology effects of live attenuated hepatitis A vaccine in different doses and schedules groups, and compare with inactivated hepatitis A vaccine (Havrix, Smithkline).

Methods: 318 susceptible children were enrolled in Guangxi and Hebei province. These subjects were divided into six groups. Each group was vaccinated with either inactivated vaccine or different doses and schedules of live attenuated vaccine. Serum specimens were collected and tested for anti-HAV antibody at different time after the vaccination.

Results: GMT of each group arrived at the peak 1 months after re-vaccination, then declined, and GMT of 6 months after booster dose was still significantly higher than that after primary immunization. Sero-conversion rates in all groups reached 100% after a booster dose, and kept at 6 months after booster dose.

Conclusions: A booster dose of live attenuated vaccine can induce secondary immune response well. The immunology effects after booster dose are comparable with inactivated vaccine and it should be useful to the immune persistence.