[Association between cytochrome P-450 enzyme gene polymorphisms and Parkinson's disease]

Abstract

Objective: To explore the association between cytochrome P-450 enzyme gene polymorphisms and Parkinson's disease (PD).

Methods: The polymorphisms of CYP1A1 and CYP2E1 gene were analyzed in 158 PD patients and 150 unrelated healthy controls with PCR-RFLP and ASA techniques.

Results: (1) Of the 46 patients with early-onset PD, the frequency of the m2 allele was significantly higher than that in their matched controls, with an odds ratio of 2.459 (P < 0.005); the frequencies of the m1m2 and m2m2 genotypes were significantly higher than those in their matched controls with odds ratios of 2.99 (P < 0.01) and 6.22 (P < 0.025), respectively. In contrast, no differences were observed when the frequencies of individuals with the CYP1A1 MspI alleles or genotypes among patients with late-onset PD and their matched controls were compared (all P > 0.05). (2) Of the 46 patients with early-onset PD, the frequency of the G allele was significantly higher than that in their matched controls, with an odds ratio of 2.432 (P < 0.005); odds ratio was 6.167 in homozygotes for G allele (P < 0.01). Similarly, the frequency of the G allele was also significantly higher in late-onset PD patients than in their matched controls, with only an odds ratio of 1.649 (P < 0.01). In contrast, no differences were observed when the frequencies of individuals with the CYP1A1 exon 7 A4889G polymorphic locus genotypes among patients with late-onset PD and their matched controls were compared (P > 0.05). (3) No differences were observed when the frequencies of individuals with the CYP2E1 RsaI and PstI alleles or genotypes among patients with early- and late-onset PD and their matched controls were compared (all P > 0.05).

Conclusions: Our data suggest that CYP1A1 gene polymorphisms might be a genetic susceptible factor for early-onset PD, and CYP2E1 RsaI and PstI polymorphisms might not be a genetic susceptible factor for both early- and late-onset PD in the Chinese population tested.