[Family study of genomic imprinting in tic disorder]

Abstract

Objective: To investigate whether genomic imprinting is involved in the etiology of tic disorder.

Methods: International standard structural schedule for the genetic research of tic disorder and standard process of phenotype evaluation, in addition to both family study method and family history method were used in the family study of 171 probands with tic disorder.

Results: Maternal transmission was associated with the symptom of complex motor tics in the probands (beta ratio = 6.6, P = 0.01); Maternal transmission was more likely to present earlier-onset of the disease (Log Rank = 4.71, P = 0.029); However, paternally transmitted tic disorder was characterized by increased attention problem score in CBCL behavioral scale among the proband (t = 2.78, chi(2) = 0.01).

Conclusion: Parental specific expression exists in the transmission of tic disorder, which gives evidence that genomic imprinting may be involved in the genetic mechanism of tic disorder.